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Loss of MEN1 leads to renal fibrosis and decreases HGF-Adamts5 pathway activity via an epigenetic mechanism.
Jin B, Zhu J, Zhou Y, Liang L, Yang Y, Xu L, Zhang T, Li P, Pan T, Guo B, Chen T, Li H. Jin B, et al. Clin Transl Med. 2022 Aug;12(8):e982. doi: 10.1002/ctm2.982. Clin Transl Med. 2022. PMID: 35968938 Free PMC article.
BACKGROUND: Renal fibrosis is a serious condition that results in the development of chronic kidney diseases. ...Mechanistically, menin recruits and increases H3K4me3 at the promoter regions of hepatocyte growth factor (HGF) and a disintegrin and metalloproteinase with thr …
BACKGROUND: Renal fibrosis is a serious condition that results in the development of chronic kidney diseases. ...Mechanistically, men …
Growth hormone secretagogues modulate inflammation and fibrosis in mdx mouse model of Duchenne muscular dystrophy.
Boccanegra B, Cappellari O, Mantuano P, Trisciuzzi D, Mele A, Tulimiero L, De Bellis M, Cirmi S, Sanarica F, Cerchiara AG, Conte E, Meanti R, Rizzi L, Bresciani E, Denoyelle S, Fehrentz JA, Cruciani G, Nicolotti O, Liantonio A, Torsello A, De Luca A. Boccanegra B, et al. Front Immunol. 2023 Apr 12;14:1119888. doi: 10.3389/fimmu.2023.1119888. eCollection 2023. Front Immunol. 2023. PMID: 37122711 Free PMC article.
In parallel, GHSs also reduced diaphragm (DIA) and gastrocnemius (GC) ultrasound echodensity, a fibrosis-related parameter (RS: ranging between 26% and 75%). Ex vivo, both drugs ameliorated DIA isometric force and calcium-related indices (e.g., RS: 40% for tetanic force). …
In parallel, GHSs also reduced diaphragm (DIA) and gastrocnemius (GC) ultrasound echodensity, a fibrosis-related parameter (RS: rangi …
Knockout of ADAMTS5 does not eliminate cartilage aggrecanase activity but abrogates joint fibrosis and promotes cartilage aggrecan deposition in murine osteoarthritis models.
Li J, Anemaet W, Diaz MA, Buchanan S, Tortorella M, Malfait AM, Mikecz K, Sandy JD, Plaas A. Li J, et al. J Orthop Res. 2011 Apr;29(4):516-22. doi: 10.1002/jor.21215. Epub 2010 Oct 26. J Orthop Res. 2011. PMID: 21337391 Free article.
In the TTR model, ADAMTS5 ablation did not eliminate aggrecanase activity from the articular cartilage but blocked fibrosis and resulted in the accumulation of aggrecan in the articular cartilage. The cartilage protection provided by ADAMTS5 ablation in the m …
In the TTR model, ADAMTS5 ablation did not eliminate aggrecanase activity from the articular cartilage but blocked fibrosis an …
Hyaluronan injection in murine osteoarthritis prevents TGFbeta 1-induced synovial neovascularization and fibrosis and maintains articular cartilage integrity by a CD44-dependent mechanism.
Li J, Gorski DJ, Anemaet W, Velasco J, Takeuchi J, Sandy JD, Plaas A. Li J, et al. Arthritis Res Ther. 2012 Jun 21;14(3):R151. doi: 10.1186/ar3887. Arthritis Res Ther. 2012. PMID: 22721434 Free PMC article.
Gene expression in joint tissues for Acan, Col1a1, Col2a1, Col3a1, Col5a1, Col10a1, Adamts5 and Mmp13 was done by quantitative PCR. The abundance and distribution of aggrecan, collagen types I, II, III, V and X, ADAMTS5 and MMP13 were examined by immunohistochemistr …
Gene expression in joint tissues for Acan, Col1a1, Col2a1, Col3a1, Col5a1, Col10a1, Adamts5 and Mmp13 was done by quantitative PCR. T …
Intraarticular injection of hyaluronan prevents cartilage erosion, periarticular fibrosis and mechanical allodynia and normalizes stance time in murine knee osteoarthritis.
Plaas A, Li J, Riesco J, Das R, Sandy JD, Harrison A. Plaas A, et al. Arthritis Res Ther. 2011 Mar 20;13(2):R46. doi: 10.1186/ar3286. Arthritis Res Ther. 2011. PMID: 21418601 Free PMC article.
A single injection of HA prevents acute and prolonged gait changes and ameliorates the cartilage erosion and periarticular fibrosis normally seen in this model. We speculate that the capacity of HA to prevent cartilage erosion results from its normalization of joint biomec …
A single injection of HA prevents acute and prolonged gait changes and ameliorates the cartilage erosion and periarticular fibrosis n …
In Silico Identification of Contradictory Role of ADAMTS5 in Hepatocellular Carcinoma.
Zhu Z, Xu J, Wu X, Lin S, Li L, Ye W, Huang Z. Zhu Z, et al. Technol Cancer Res Treat. 2021 Jan-Dec;20:1533033820986826. doi: 10.1177/1533033820986826. Technol Cancer Res Treat. 2021. PMID: 33522433 Free PMC article.
BACKGROUND: ADAMTS5 has different roles in multiple types of cancers and participates in various molecular mechanisms. However, the prognostic value of ADAMTS5 in patients with hepatocellular carcinoma (HCC) still remains unclear. ...
BACKGROUND: ADAMTS5 has different roles in multiple types of cancers and participates in various molecular mechanisms. However, the p …
ADAMTS5 deficiency protects against non-alcoholic steatohepatitis in obesity.
Bauters D, Spincemaille P, Geys L, Cassiman D, Vermeersch P, Bedossa P, Scroyen I, Lijnen HR. Bauters D, et al. Liver Int. 2016 Dec;36(12):1848-1859. doi: 10.1111/liv.13181. Epub 2016 Jul 4. Liver Int. 2016. PMID: 27254774
However, no information is available on a potential role in liver pathology. We studied the effect of ADAMTS5 deficiency on NASH in mice. METHODS: Wild-type (Adamts5(+/+) ) and deficient (Adamts5(-/-) ) mice were kept on a standard- or high-fat diet (HFD) for …
However, no information is available on a potential role in liver pathology. We studied the effect of ADAMTS5 deficiency on NASH in m …
Adamts5 deletion blocks murine dermal repair through CD44-mediated aggrecan accumulation and modulation of transforming growth factor beta1 (TGFbeta1) signaling.
Velasco J, Li J, DiPietro L, Stepp MA, Sandy JD, Plaas A. Velasco J, et al. J Biol Chem. 2011 Jul 22;286(29):26016-27. doi: 10.1074/jbc.M110.208694. Epub 2011 May 12. J Biol Chem. 2011. PMID: 21566131 Free PMC article.
ADAMTS5 has been implicated in the degradation of cartilage aggrecan in human osteoarthritis. ...TGFbeta1 treatment of newborn fibroblasts from wild type mice results in Smad2/3 phosphorylation, whereas cells from Adamts5(-/-) mice phosphorylate Smad1/5/8. The alter …
ADAMTS5 has been implicated in the degradation of cartilage aggrecan in human osteoarthritis. ...TGFbeta1 treatment of newborn fibrob …
LncRNA XIST promotes mitochondrial dysfunction of hepatocytes to aggravate hepatic fibrogenesis via miR-539-3p/ADAMTS5 axis.
Wu XJ, Xie Y, Gu XX, Zhu HY, Huang LX. Wu XJ, et al. Mol Cell Biochem. 2023 Feb;478(2):291-303. doi: 10.1007/s11010-022-04506-0. Epub 2022 Jul 6. Mol Cell Biochem. 2023. PMID: 35794289
Considering the critical role of HSC activation in hepatic fibrosis, the aim of the present study was to reveal the exact role of XIST in liver fibrosis and its underlying mechanism. ...This study may provide a potential therapeutic strategy for the treatment of liv …
Considering the critical role of HSC activation in hepatic fibrosis, the aim of the present study was to reveal the exact role of XIS …
Versican: a novel modulator of hepatic fibrosis.
Bukong TN, Maurice SB, Chahal B, Schaeffer DF, Winwood PJ. Bukong TN, et al. Lab Invest. 2016 Mar;96(3):361-74. doi: 10.1038/labinvest.2015.152. Epub 2016 Jan 11. Lab Invest. 2016. PMID: 26752747 Free article.
Hepatic fibrosis was induced by carbon tetrachloride treatment of C57BL/6 mice over 4 weeks followed by recovery over a 28-day period. ...Versican expression increases during HSC activation and liver fibrosis, and proteolytic processing occurs during the resolution …
Hepatic fibrosis was induced by carbon tetrachloride treatment of C57BL/6 mice over 4 weeks followed by recovery over a 28-day period …
19 results